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Year : 1997  |  Volume : 29  |  Issue : 1  |  Page : 3-10

An update on pharmacological prospectives for prevention and development of cataract



Correspondence Address:
S K Gupta


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Source of Support: None, Conflict of Interest: None


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Cataract is one of the leading causes of visual disability, often leading to blindness. The situation can be remedied surgically by extirpation of the cataractous lens. Various pharmacological strategies have been proposed for prevention and treatment of cataract. The present article deals with the wholearea from aldose reductase inhibitors (ARI) through aspirin, ibuprofen, bendazac, glutathione boosters, antiglycating agents, vitamins and various drugs from indigenous sources. Recently various substances with dietse chemical structures and properties have been claimed to possess anti-cataract potential in experimental models. Some of them have been evaluated in clinical trials but failed in final stages due to adverse side effects. Till day no anti-cataract drug is approved for the medical therapy of cataract anywhere in the world. However, agents with un-proven efficacy are available in some developing countries. It is probable that some agents will come up soon and will be useful in delaying the onset and progression of cataract formation in humans.






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