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Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 257-260

Human chorionic gonadotrophin (hcG) protects malathion induced plasma luteinizing hormone and testosterone changes in rats



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N Prakash


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Effect of malathion, an organophosphate compound on plasma concentration of luteinizing hormone (LH) and testosterone (T4) was studied in adult male rats. A single s.c administration of malathion (23 mg/kg, 1/5Oth LD50 dose) significantly (P( 0.05) reduced plasmaconcentration of both LH and T4 at 24,36 and 48 h post-treatment. Prior administration of human chorionic gonadotrophins (hcG, 50 IU) for two days at 24 h interval protected the malathion induced hormonal changes. These results suggest that malathion induced inhibition of testicular steroidogenesis may be due to its cholinergic activity influencing central mechanisms involved in LH secretion and/or release.






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