IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1236 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1998    
    Printed116    
    Emailed4    
    PDF Downloaded358    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 232-239

Protective action of ursolic acid against chemical induced hepato-toxicity in rats



Correspondence Address:
Saraswat Binduja


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Ursolic acid isolated from the leaves of Eucalyptus hybrid E. tereticomis showed a dose dependent (5-20 mg/kg) hepatoprotective activity (21-l 00%) in rats against thioacetamide, galactosamine and carbon tetrachloride induced hepatotoxicity in rats. These hepatotoxins decreased the viability of hepatocytes as assessed by trypan blue exclusion and rate of oxygen uptake tests and decreased the volume of bile as well as the level of its contents. Pretreatment with ursolic acid increased the viability of rat hepatocytes significantly. A potent dose dependent antlcholestatic activity was observed in conscious rat by noticing an increase in bile flow and its contents. Ursolic acid had comparable activity to that of silymarin.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow