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 RESEARCH PAPER
Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 227-231

Evaluation of CC-2 as a decontaminant at various time intervals against topically applied sulphur mustard in mice



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PMK Reddy


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Decontamination of bis (2-chloroethyl) sulphide, commonly known as sulphur mustard (SM), from the skin is recommended as the best protection against its toxicity as there are no specific antidotes for SM. In the present study the decontamination efficacy of N,N'-dichloro-bis [2,4,6-trichlorophenyl] urea known as CC-2, was evaluated against SM, applied dermally. CC-2 was prepared as a formulation either in Fuller's earth (native aluminium silicate) or in white ointment USP in 20:80 ratio (w/w). 20 'l of SM (equivalent to 6 LD50) was applied on the back of mice after closely clipping the hair and then decontaminated with various agents viz., Fuller's earth alone, CC-2 Fuller's earth, ointment alone or CC-2 ointment, by smearing on the applied area and gently wiping it off (200 mg of the agent, twice). The animals were monitored for 14 days after decontamination. The decontamination efficacy was also evaluated with respect to time by decontaminating SM at various time intervals viz., 0.5, 2, 5, 10 or 20 min, after using various agents, following application of SM. The study showed that the decontamination efficacy was maximum with CC-2 Fuller's earth. The order of efficacy was CC-2 Fuller's earth > Fuller's earth alone > CC-2 ointment > ointmentalone = control. The study also showed that the decontamination efficacy is dependent upon the time. The order of efficacy was 0.5 > 2.0 > 5.0 = 10.0 = 20.0. Further CC-2 Fuller's earth and CC-2 ointment were found non-irritant based on rabbit primary skin irritation test.






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