IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 220-223

Opiate excretion profile among heroin dependent subjects by TLC densitometry



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Jain Raka


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Urinary excretion profile of total morphine (free and conjugated) was examined in human volunteers after acute administration. Six heroin dependent subjects received single intramuscular injection of 30 mg morphine following their detoxification. Serial urine specimens were collected before and al libitum for 48 h following administration of the drug. Morphine was assayed by thin layer chromatography (TLC) and densitometric methods. Peak concentration was observed within 5 h and the drug was detectable up to 12 h. Total morphine excreted by 12 h was about 61% of total dose. Detection limit of total morphine in our laboratory by the above techniques was 0.5 (glml. The TLC and densitometric techniques are simple, rapid and may be used for detecting morphine in heroin dependent subjects.






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