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Year : 1996  |  Volume : 28  |  Issue : 3  |  Page : 191-193

Calcium blocking potencies of some antimalarials on isolated rat aortic strip preparation



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P I Aziba


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The calcium channel blocking activities of equimolar concentration of chloroquine, amodiaquine, mepacrine, quinine and mefloquine were examined on the rat isolated aortic strip and compared with that of diltiazem, a classical organic Ca2+ channel blocker. All antimalarial drugs as well as diltiazem non-competitively inhibited the contractile effect of calcium chloride. They displaced response curve in a non-parallel fashion to the right with depressed maxima. Amon antimalarial drugs, chloroquine and amodiaquine were equipotent with Ic70 of 2.15(0.2 x 10-6 M, while mefloquine was the least potent (lc70 of 5.2(0.4 x 10-6 M) although chloroquine was at least 1,000 times less potent (on molar basis) than diltiazem as a Ca2+channel blocker in this preparation. It was concluded that antimalarial drugs possessed appreciable Ca2+ channel blocking activities, although much less than diltiazem.






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