IPSIndian Journal of Pharmacology
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Year : 1996  |  Volume : 28  |  Issue : 3  |  Page : 181-184

Evaluation of clinical efficacy and safety of hydroxyethyl starch

Correspondence Address:
Rani P Usha

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Source of Support: None, Conflict of Interest: None

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Hydroxyethyl starch (HES) 6% has been shown to improve hypovolaemia, with minimum side effects and long duration of action. Thirty patients showing signs of hypovolaemia post-operatively, in the form of tachycardia and hypotension received 500 ml of 6% HES intravenously over 30-60 minutes. Administration of HES, significantly improved hypovolaemia in all the patients. Within 30 minutes after infusion, systolic blood pressure (SBP) increased from 85 6 to 98 8 mm Hg. Heart rate decreased from 124 3 beats per minute (bpm) to 99 6 bpm and central venous pressure (CVP) increased from 1 1 to 3.5k1.2 cm of saline, at one hour post HES administration. This improvement persisted till the end of sixth hour observation period. All patients tolerated HES well without any side effects and hematological or biochemical abnormalities.


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