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 RESEARCH PAPER
Year : 1996  |  Volume : 28  |  Issue : 3  |  Page : 167-170

Modification of duodenal ulcer by calcium channel blockers in rats



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Jain Sunita


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Effects of three calcium channel blockers viz., verapamil, nifedipine and diltiazem were studied against experimentally induced duodenal ulcers. The parameters studied include ulcer incidence, score for intensity, total lesion area and mortality rate using cysteamine-induced duodenal ulcer model. Verapamil (i.p.)was found to produce significant reduction in both score for intensity and total lesion area at 32 mglkg dose. Nifedipine (p.o)showed significant reduction in total lesion area at 32 mg/kg dose. Paradoxically diltiazem (i.p.) and low dose of nifedipine exacerbated the cysteamine ulcers.






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