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 RESEARCH PAPER
Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 93-97

Glutathione and glutathione redox cycle in riboflavin supplemented cataractous rat lenses



Correspondence Address:
R R Vani


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Effect of riboflavin supplementation on glutathione and glutathione redox cycle in selenite induced cataractous rat lenses was studied, as the lens negates some of the toxic effects of the oxidants by its glutathione mediated defence mechanisms. The alterations in the level of proteins, reduced glutathione (GSH) and the activity of (-glutamylcysteine synthetase ((-GCS), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) have been studied in the control and riboflavin supplemented rats. The cataractous littermates supplemented with riboflavin showed increased activity of the enzymes and elevated levels of metabolites as compared to the cataractous, non-supplemented littermates. The results of this study point towards the role of riboflavin in the prevention of cataract, induced by selenite.






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