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 RESEARCH PAPER
Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 88-92

Optimizing dosage regimens of liposomal amphotericin B using aspergillus murine model



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R N Kotwani


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Amphotericin B remains the drug of choice in most systemic mycoses, but its use is often limited by its severe side effects. Liposomal encapsulation of amphotericin B has been shown to improve tolerance without compromising efficacy. In this study, the dosage regimens and frequency of administration of liposomal amphotericin B prepared using soya phosphatidylcholine and cholesterol given prophylactically or therapeutically in mice infected with Aspergillus fumigatus was assessed. Liposomal amphotericin B was more effective than free amphotericin B on an equal dose basis when given therapeutically. A large single dose of liposomal amphotericin B was more effective, both prophylactically and therapeutically, than two divided doses of the total dose.






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