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 RESEARCH PAPER
Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 72-76

Pharmacological Study of the toad skin extract on experimental animals



Correspondence Address:
Das Manika


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Toad (Bufo melanostictus) skin a rich source of bioactive compounds, was explored for possible pharmacological effects on experimental animals. The LD50 of toad skin extract (TSE) was found to be 400 mg/kg, (iv) in male albino mice. TSE produced significant hyperthermia and potentiated pentobarbitone induced sleeping time in male albino mice. TSE produced apnoea in cat and rat. It produced a biphasic response, hypotension followed by hypertension in cat and the latter action was blocked by atropine. On isolated heart of guinea pig TSE produced negative chronotropic, positive ionotropic effect and produced reversible blockade of guinea pig auricular contraction. Atropine blocked TSE induced contractile response on guinea pig isolated ileum and rat fundus. Electrical stimulation induced twitch response of chick isolated biventer cervices was inhibited by TSE but it had no effect on the isolated rat phrenic nerve diaphragm preparation. TSE did not possess haemorrhagic activity but produced strong haemolytic activity.






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