| RESEARCH PAPER
|Year : 1996 | Volume
| Issue : 2 | Page : 102-106
Role of central serotonergic system in immunomodulation in rats
D Kumar, HC Tripathi, SK Mishra, SK Tandan, V Raviprakash, SC Mishra
5-hydroxytryptophan (5-HTP), a precursor of serotonin and para chlorophenylalanine (PCPA), a serotonin synthesis blocker, were administered centrally in immunized rats to investigate the role of central serotonergic system in immunomodulation. 5-HTP treatment prior to immunization significantly inhibited the cell mediated as well as humoral immune response. However, plasma corticosterone levels remained unaffected. Post-immunization treatment with 5-HTP did not produce any effect on immune response and plasma corticosterone levels. PCPA administered prior to immunization markedly stimulated the cell-mediated as well as humoral immune response but there was no effect on plasma corticosterone levels.Cell mediated immune response was, however, reduced significantly with a concomitant increase in the plasma corticosterone levels in the rats treated with PCPA after immunization. It is suggested that the central serotonergic system plays a critical role in immunomodulation.
Source of Support: None, Conflict of Interest: None