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 RESEARCH PAPER
Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 102-106

Role of central serotonergic system in immunomodulation in rats



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D Kumar


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5-hydroxytryptophan (5-HTP), a precursor of serotonin and para chlorophenylalanine (PCPA), a serotonin synthesis blocker, were administered centrally in immunized rats to investigate the role of central serotonergic system in immunomodulation. 5-HTP treatment prior to immunization significantly inhibited the cell mediated as well as humoral immune response. However, plasma corticosterone levels remained unaffected. Post-immunization treatment with 5-HTP did not produce any effect on immune response and plasma corticosterone levels. PCPA administered prior to immunization markedly stimulated the cell-mediated as well as humoral immune response but there was no effect on plasma corticosterone levels.Cell mediated immune response was, however, reduced significantly with a concomitant increase in the plasma corticosterone levels in the rats treated with PCPA after immunization. It is suggested that the central serotonergic system plays a critical role in immunomodulation.






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