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Year : 1995  |  Volume : 27  |  Issue : 4  |  Page : 245-249

Neurobehavioural effects of acute monocrotophos administration in rats and mice



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S N Mandhane


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A study was conducted on rats and mice to assess the acute behavioral toxicity of oral monocrotophos (MCP). MCP produced hypothermia, reduced locomotor activity and affected the ability of trained mice to ride on rotating rod. Doses as low as 2, 1 and 4 mg/kg were required for these effects respectively. MCP (l-4 mg/kg) caused potentiation of pentobarbitone (40 mg/kg, ip) sedation and haloperidol (1 mg/kg, ip) induced catalepsy. However, pentylenetetrazole (SO mg/kg, SC) induced tonic-clonic convulsions and mortality were not affected. MCP at these doses per se had no hypnotic, cataleptic or convulsant effects. These results suggest that MCP is a potent CNS depressant compound which may cause adverse neurobehavioral effects in mammals.






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