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 RESEARCH PAPER
Year : 1995  |  Volume : 27  |  Issue : 4  |  Page : 230-233

Inhibition of antigen and compound 48/80 induced contractions of Guinea pig trachea by the ethanolic extract of the leaves of Vitex negundo Linn



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A M Nair


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The ethanolic extract of Vitex negundo was studied for its effect on the sensitised and non-sensitised guinea pig trachea using antigen and compound 48/80 respectively to examine its influence on mediator release and tracheal smooth muscle contraction. Histamine has been shown to contribute only to the initial phase of tracheal contraction while the release of lipoxygenase derived arachidonic acid metabolites have been reported to contribute to the later sustained contraction. The ethanolic extract of V.negundo was found to significantly inhibit both the initial phase of contraction and the later sustained contracture of the trachea. The studies reveal that the ethanolic extract of Knegundo inhibits the release of histamine and products of arachidonic acid metabolism.






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