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 REVIEW ARTICLE
Year : 1995  |  Volume : 27  |  Issue : 4  |  Page : 214-221

Neurosteroids: novel regulators of neural functions



Correspondence Address:
M R Jain


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Source of Support: None, Conflict of Interest: None


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Recent studies have demonstrated that some of the enzymes involved in the biosynthesis of steroidal hormones are found in a cell specific and region specific fashion in the brain. The discovery of the biosynthesis of steroids in the brain has generated considerable ex citement. These brain derived steroids (named 'neurosteroids'), in addition to binding to the cytoplasmic/nuclear receptors also interact with the specific binding sites on the GABAA receptor. Several biological functions have been proposed for these neurosteroids for their roles in hypnosis, anxiety, analgesia, convulsion, neural development and regulation of endocrine systems, Although in its infancy, the study of the neurosteroids is an emerging line that has shown considerable potential. It is hoped that the work on neurosteroids in addition to throwing new light on the neural processes, may provide a substratum for the development of new drugs for several neural disorders.






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