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Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 183-185

Rifampicin pretreatment reduces bioavailability of diclofenac sodium



Correspondence Address:
Kumar J Surya


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Diclofenac sodium 100 mg (2 x 50 mg enteric coated tablets) alone and in combination with rifampicin 600 mg as a single dose (group I and group II respectively) was administered to six healthy human volunteers in a cross over design. In the second study diclofenac sodium 100 mg was administered after a six day treatment with rifampicin 450 mg daily (Group Ill). Plasma concentrations of diclofenac were determined during a 8 hour period following drug administration. The mean peak plasma concentrations (Cmax) were 5.28, 6.68 and 2.99 fig/ml, time taken to reach. the peak (Tmax) were 3.17, 3.25 and 2.5 hrs and area under curve[AUC(0-()] were 14.17, 13.74 and 4.63 ug.hr/ml in the groups I, II and Ill respectively. Statistically a significant difference was observed in Cmax , AUC(0-() (P < 0.01) and Cl/f (P < 0.05) of diclofenac sodium when administered after six days treatment with rifampicin. However, there was no difference in pharmacokinetic parameters when diclofenac was administered with rifampicin as a single dose.






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