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 RESEARCH PAPER
Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 161-166

Possible mechanism of anthelmintic action of palasonin on Ascaridia Galli



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D Kumar


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The biochemical mechanism of anthelmintic action of palasonin the active principle of Butea frondosa seeds has been investigated on Ascaridia galli. Palasonin inhibited the glucose uptake and depleted the glycogen content in the presence of glucose indicating that palasonin affects the energy generating mechanism of the parasite. It also significantly increased the lactic acid suggesting inhibition of ATP production or accumulation of lactic acid. Palasonin had no effect on AChE activity, though it potentiated the spasmogenic effect of ACh on toad Rectus abdominis muscle. The frequency and magnitude of spontaneous contractions of A.galli were significantly inhibited by palasonin. Following 20 h incubation of A.gal li with palasonin, a significant inhibition in the gross visual motility was also observed. In conclusion, the possible mechanism of anthelmintic action of palasonin may be related to either inhibition of energy metabolism and/ or alteration in the motor activity of the parasite.






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