IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 906 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2088    
    Printed86    
    Emailed0    
    PDF Downloaded201    
    Comments [Add]    

Recommend this journal

 

 SHORT COMMUNICATION
Year : 1995  |  Volume : 27  |  Issue : 2  |  Page : 130-132

Percutaneous absorption of naproxen from different ointment bases in rats



Correspondence Address:
MSP Sastry


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Percutaneous absorption of naproxen from three different ointment bases viz, water washable transparent carbopol gel, water soluble PEG and oleagenous petroleum jelly bases in rats was evaluated indirectly by estimating the % unabsorbed drug at different time intervals after the application of the ointments. Rate of drug absorption (Ka) was faster from gel base (0.36h-1), followed by PEG (0.26h-1) and petroleum jelly (0.12h-1) bases with the corresponding absorption half-lives (t1/2) of 1.93 hrs, 2.67 hrs and 5.78 hrs respectively. The same order of drug absorption was also observed from the three different bases in the in viw plasma concentration time profiles indicating a good correlation between in vivo and % unabsorbed drug studies.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow