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 CONFERENCE ABSTRACTS
Year : 1995  |  Volume : 27  |  Issue : 1  |  Page : 45-81

Abstracts of research papers presented in the XXVII Annual conference of Indian pharmacological society, December 21-24, 1994, Bombay


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The present study was undertaken to investigate the effects of testosterone, 17-( - estradiol and castration on serum alkaline phosphatase isoenzymes in male rats. Daily administration of testosterone (2 mg/kg) for 15, 30 and 60 days increased serum total alkaline phosphatase activity by 9, 26 and 65 percent respectively. Estradiol administration (0.2 mg/kg) in the same periods led to the increase of 69, 67 and 68 percent. Enzyme fractionation on sephacryl S-300 revealed that the increase in alkaline phosphatase activity was due to the absolute elevation of low-molecular weight alkaline phosphatase isoenzyme. Castration or treatment with actinomvcin-D puromvcin of the animal diminished enzyme activity bv 28-37 percent. The estradiol induced increase in enzymeactivity had additive effect with puromycin or actinomycin D in the doses used.






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