IPSIndian Journal of Pharmacology
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Year : 1995  |  Volume : 27  |  Issue : 1  |  Page : 34-36

Effect of nifedipine on glucose tolerance in normal volunteers and patients with diabetes mellitus



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R N Chattopadhyay


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Effect of nifedipine on glucose tolerance in normal volunteers and patients with diabetes mellitus was studied. Nifedipine (10 mg) produced no significant change on glucose tolerance in normal individuals, But in diabetic individuals, nifedipine produced a significant reduction in glucose tolerance at half an hour after glucose load. However, no such reduction was observed at one and two hours after glucose load. There is a possibility that nifedipine exerts inhibitory effect on insulin release specially in the initial phase in diabetic individuals but not in healthy volunteers.






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