| RESEARCH PAPER
|Year : 1994 | Volume
| Issue : 4 | Page : 296-300
Effect of diterpenes from Andrographis paniculata on antioxidant defense system and lipid peroxidation
IB Koul, A Kapil
In the present study, the effect of the diterpenes i.e., andrographolide (I), andrographiside (II) and neoandrographolide (Ill) from Andrographis paniculata was investigated on the hepatocellular antioxidant defense system in CCl4 - treated mice. lntraperitoneal administration of the diterpenes at a dose of 100 mg/kg b.wt for 7 days caused a significant elevation in different components of cellular antioxidant defense and reduction in lipid peroxidation, revealing that the antioxidant action may play a role in the antihepatotoxic activity of the diterpenes. A comparison with silymarin, a standard hepatoprotective agent, showed that Ill was as effective as silymarin (SM) with respect to its effect on reduced glutathione (GSH), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in the intoxicated animals, whereas in II treated group only antilipoperoxidant response was as prominent as that of SM treated group.
I B Koul
Source of Support: None, Conflict of Interest: None