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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 296-300

Effect of diterpenes from Andrographis paniculata on antioxidant defense system and lipid peroxidation



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I B Koul


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In the present study, the effect of the diterpenes i.e., andrographolide (I), andrographiside (II) and neoandrographolide (Ill) from Andrographis paniculata was investigated on the hepatocellular antioxidant defense system in CCl4 - treated mice. lntraperitoneal administration of the diterpenes at a dose of 100 mg/kg b.wt for 7 days caused a significant elevation in different components of cellular antioxidant defense and reduction in lipid peroxidation, revealing that the antioxidant action may play a role in the antihepatotoxic activity of the diterpenes. A comparison with silymarin, a standard hepatoprotective agent, showed that Ill was as effective as silymarin (SM) with respect to its effect on reduced glutathione (GSH), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in the intoxicated animals, whereas in II treated group only antilipoperoxidant response was as prominent as that of SM treated group.






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