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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 292-295

Effect of BR-16A on alpha-2 adrenergic, dopamine autoreceptor and dopamine postsynaptic receptor functioning



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C Andrade


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BR-16A is a herbal preparation with possible neuropsychiatric effects; preclinical work has found it to facilitate cognition and diminish both anterograde and retrograde amnesia induced by electroconvulsive shocks. The present study sought to assess whether BR-16A affects adrenergic and dopaminergic functioning in the brain. Adult, male, Sprague-Dawley rats which received BR-l 6A (200 mg/kg/day) or vehicle for one month were challenged with clonidine (100 (g/kg s.c.), apomorphine (2 mg/kg, 100 (g/kg or 50 (glkg, s.c.) or saline in separate factorial design experiments. Following the challenge, motility of the animals was assessed using a small open field. BR-l 6A did not influence hypomotility induced by clonidine agonism at alpha-2 adrenergic receptors nor by low dose apomorphine agonism at dopamine autoreceptors. However, BR 16A did augment high dose apomorphine-induced dopamine postsynaptic receptor-mediated hypermotility. These results suggest that BR-l6A does not interfere with alpha-2 adrenergic and dopamine autoreceptor functioning, and that it enhances dopamine postsynaptic receptor activity.






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