| RESEARCH PAPER
|Year : 1994 | Volume
| Issue : 4 | Page : 266-269
Studies on the antiproliferative effect of some naturally occurring bioflavonoidal compounds against human carcinoma of larynx and Sarcoma-180 cell lines
V Elangovan, Ramamoorthy Nalini, S Balasubramanian, N Sekar, S Govindasamy
In vitro effects of bioflavonoids namely quercetin, (+) catechin, luteolin and rutin against human carcinoma of larynx (HEp-2) and sarcoma-l 80 (S-l 80) cell lines were studied. It was observed that the flavonoid luteolin inhibited the proliferation of these cells and the inhibiiory concentration (IC50) was found to be 21 (g/ml which was closely equal to plumbagin (10( g), an anticancer drug. At 28 (g/ml concentration, quercetin showed 50% cell death in HEp-2 cells and in S-l 80, the inhibition was less. Depletion of glutathione in the cells coupled with loss of cell viability was observed in the luteolin treated cultures. Further, [3H] thymidine uptake studies revealed a decline in DNA synthesis in the presence of luteolin.