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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 266-269

Studies on the antiproliferative effect of some naturally occurring bioflavonoidal compounds against human carcinoma of larynx and Sarcoma-180 cell lines


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V Elangovan


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In vitro effects of bioflavonoids namely quercetin, (+) catechin, luteolin and rutin against human carcinoma of larynx (HEp-2) and sarcoma-l 80 (S-l 80) cell lines were studied. It was observed that the flavonoid luteolin inhibited the proliferation of these cells and the inhibiiory concentration (IC50) was found to be 21 (g/ml which was closely equal to plumbagin (10( g), an anticancer drug. At 28 (g/ml concentration, quercetin showed 50% cell death in HEp-2 cells and in S-l 80, the inhibition was less. Depletion of glutathione in the cells coupled with loss of cell viability was observed in the luteolin treated cultures. Further, [3H] thymidine uptake studies revealed a decline in DNA synthesis in the presence of luteolin.






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