IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 594 
Small font sizeDefault font sizeIncrease font size
Navigate Here
    Next article
    Previous article
    Table of Contents

Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded256    
    Comments [Add]    
    Cited by others 10    

Recommend this journal


Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 266-269

Studies on the antiproliferative effect of some naturally occurring bioflavonoidal compounds against human carcinoma of larynx and Sarcoma-180 cell lines

Correspondence Address:
V Elangovan

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

In vitro effects of bioflavonoids namely quercetin, (+) catechin, luteolin and rutin against human carcinoma of larynx (HEp-2) and sarcoma-l 80 (S-l 80) cell lines were studied. It was observed that the flavonoid luteolin inhibited the proliferation of these cells and the inhibiiory concentration (IC50) was found to be 21 (g/ml which was closely equal to plumbagin (10( g), an anticancer drug. At 28 (g/ml concentration, quercetin showed 50% cell death in HEp-2 cells and in S-l 80, the inhibition was less. Depletion of glutathione in the cells coupled with loss of cell viability was observed in the luteolin treated cultures. Further, [3H] thymidine uptake studies revealed a decline in DNA synthesis in the presence of luteolin.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow