| SHORT COMMUNICATION
|Year : 1994 | Volume
| Issue : 3 | Page : 227-228
Anticonvulsant activity of pyrimidine thiols
AK Gupta, Sanjay, HP Kayath, Singh Ajit, Sharma Geeta, KC Mishra
A series of nitrophenyl 4,4,6 trimethyl, 1 H, 4H pyrimidine 2 thiols (NPTP) were synthesised and tested for their anticonvulsant activity in mice against maximal electro shock and metrazol (MET) induced convulsions. Test compounds were given in graded doses (20,40,60,80 mg/Kg i.p.) and compared with phenobarbitone as a standard control. The protection produced by the test compounds was dose dependent. Phenobarbitone, produced 100% protection in the dose of 50 mg/Kg, whereas test compounds exhibited the same effect with 80 mg/Kg except 2 NPTP against MET induced convulsions.
A K Gupta
Source of Support: None, Conflict of Interest: None