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 SHORT COMMUNICATION
Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 222-224

Mechanism of hyperglycaemic effect of calcium channel antagonists in Rats



Correspondence Address:
H L Dhar


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The mechanisms of action of calcium channel antagonists in producing hyperglycaemia was studied in rats, liyperglycaemic effect was found to be mainly due to reduced insulin release and its effect on overall glucose uptake by peripheral tissues. There was a significant fall in uptake of glucose by the diaphragm and skeletal muscle of the thigh while a rise in glycogen content in the liver. Serum insulin level was lowered significantly and the results were similar with all the three calcium channel antagonists studied. It is possible that glycogenesis in the liver limits the hypergfycaemic effect within physiological limit.






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