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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 213-217

Protective effect of vitamin E against CMF –induced damages in Small intestinal brush border membrane of rats



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S Subramaniam


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A protective effect of vitamin E against cytotoxic antitumor drugs (cyclophosphamide, methotrexate, 5-fluorouracil; CMF) induced damages of rat small intestine was studied. Vitamin E protects the brush border membranes (BBM) from CMF induced lipid peroxidative damages. Intestinal brush border membrane bound sucrase, maltase and alkaline phosphatase were restored by co- administration of vitamin E with CMF. Vitamin E co-administration decreased TBA reacting substances (TBARS) levels and increased the level of sulfhydryl containing membrane proteins. Cholesterol and phospholipid levels which were altered in CMF treated rats were found to be restored by co-administration of vitamin E. The results are discussed with reference to the effect of vitamin E on TBARS, SH groups, membrane bound enzymes and membrane lipid composition.






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