IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 226 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2265    
    Printed94    
    Emailed0    
    PDF Downloaded143    
    Comments [Add]    
    Cited by others 4    

Recommend this journal

 

 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 190-193

Effects of combined H1 and H2 blockers activity against histamine Induced bronchospasm in guinea pigs



Correspondence Address:
J Jena


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Both H1 and H2 blockers were studied for their protective action against histamine aerosol induced bronchospasm in guinea pigs, The H1 blockers produced significant dose dependant complete protection in some animals and significant prolongation of the exposition time in the remaining animals. Diphenhydramine was taken as the standard. The H2 blocker cimetidine also produced the same effects as the H, blockers. When both diphenhydramine and cimetidine were administered together additive effect was produced with highly significant complete protection in some animals and significant prolongation of the exposition times in the remaining animals. This suggests involvement of both H, and H2 receptors in production of histamine induced bronchospasm in guineapigs.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow