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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 169-178

Glucose homeostasis and drugs acting on CNS: Interactions with antidiabetic agents



Correspondence Address:
B Gupta


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Source of Support: None, Conflict of Interest: None


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Alteration in glucose homeostasis by the drugs acting on CNS in euglycemic or diabetic patients may pose problems for treating physicians while interpreting the data on blood sugar levels. The problem may be further aggrevated in diabetic patients maintained on antidiabetic agents because this may adversely affect the course of the disease especially in persons on long term therapy with CNS active drugs. Since this is a group of drugs with diverse chemical structure and varied pharmacodynamic/pharmacokinetic properties, no single mechanism can be ascribed in each of the reported cases. This article is an attempt to discuss the available literature and probable mechanisms involved in modification of glucose homeostasis by CNS active agents and their interaction with antidiabetic drugs.






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