IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 580 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1389    
    Printed86    
    Emailed0    
    PDF Downloaded204    
    Comments [Add]    

Recommend this journal

 

 REVIEW ARTICLE
Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 94-107

Therapeutic potentials of 5-HT receptor modulators



Correspondence Address:
Y K Gupta


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

5-hydroxytryptamine (5-HT) has become one of the most investigated and complex biogenic amines. The main receptors and their subtypes e.g. 5-HTI (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F ), 5-HT (5-HT2A, 5-HT2B and 5-HT2C) , 5-HT3 and 5-HT4 have been identified. Additional receptors e.g., 5-HT5, 5-HT6 and subtypes of 5-HT3 have been proposed. Specific drugs which are capable of either selectively stimulating or inhibiting these receptor subtypes are being designed. This has generated great interest in exploring the therapeutic potentials of 5-HT receptor modulators in a variety of disease conditions. Conditions where 5-HT receptor modulators have established their use with distinct efficacy and advantages include migraine, anxiety and cancer therapy-induced vomiting by cytotoxic drugs and radiation. Based on the knowledge of their role in the pathophysiology of diseases, findings of animal experiments or early clinical trials, these agents have shown promise in ameliorating a number of ailments and symptoms. The potential of 5-HT receptor modulators in pain, schizophrenia, depression, parkinsonism, drug abuse, aggression, irritable bowel syndrome, carcinoid syndrome, dyspepsia, non-cardiac chest pain, gastroesophageal reflux disease, diabetic gastroparesis, hypertension, peripheral vascular diseases and glaucoma have been discussed in this article.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow