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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 159-161

Adenosine enhances analgesic effect of tricyclic antidepressants



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S S Pareek


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lntraperitoneal administration of adenosine (10 mg/kg) enhanced the analgesic effect of tricyclic antidepressant (TCA) imipramine or amitriptyline in the tail flick test. Theophylline (50 mg/kg) or caffeine (50 mg/kg), purinoceptor antagonists, attenuated the analgesic response not only of TCA alone but also of adenosine and TCA combination. These results indicate that TCA induced analgesia may be mediated through adenosinergic system and thus provide new evidence for their interaction.






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