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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 156-158

Effect of pyrogen induced fever on the biokinetics of cefazolin in goats



Correspondence Address:
B K Roy


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Biokinetics of cefazolin (CFZ) after single dose i.m. at the dose of 30 mg/kg was studied in afebrile and febrile goats. The mean cpmax of CFZ was higher (33.00 ( 2.14 (g ml-1) in afebrile as compared to that in febrile goats (19.59 (1.93 (gml-1). However, the tcpmer remained the same (4.0 h) in both the groups. The t1/2( mean value was significantly (P < 0.05) longer in the febrile goats (1.42 ( 0.14 h) as compared to that in the normal (1 .OO ( 0.04 h). The average AUC was significantly (P < 0.01) larger in normal goats (62.88 ( 4.30 (g ml-1) than that in the febrile goats (47.70 ( 2.61 (g ml-1). The dosage regimen of CFZ calculated on the basis of relevant biokinetic parameter under febrile situation has been suggested.






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