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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 153-155

Antidipsogenic action of alpha methyldopa



Correspondence Address:
A K Khare


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Source of Support: None, Conflict of Interest: None


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Acute peripheral administration of methyldopa (20 mg/kg, i.p.) attenuates drinking response in rats to acute peripheral administration of either isoproternol (25(g/kg bw, s.c.) or hypertonic saline (5 ml/kg bw, i.p.) solution. This antidipsogenic action was not different from that of acute peripheral administration of clonidine (12 (g/kg bw, i.p.). These results suggest that methyldopa has antidipsogenic effect similar to clonidine and support the view that alpha2 adrenoceptors on neuraxis are involved in mediating this effect.






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