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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 2  |  Page : 121-125

The toxicity of phaseolinone to mice



Correspondence Address:
G Bhattacharya


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The effect of phaseolinone, a phytotoxin produced by the fungus Macrophomina phaseolina, on mice was investigated. Repeated injection over a period (2 to 4 g/kg body weight divided into 45 injections) of SO days of the toxin in adult mouse induced anaemia; a significant decrease of haemoglobin content and RBC- count of blood and considerable enlargement of spleen were observed. The mitotic index of bone marrow cells was reduced. Histological study of liver and kidneys showed no change. The hematopoietic tissue region was enlarged in spleen. The 50% lethal dose (LD50) was found to be 0.98 g/kg of mouse. Infant mice were more susceptible to this toxin. Repeated injection killed a considerable percent of animals and reduced the growth rate of survivors.






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