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Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 52-54

Antagonistic effects of several adrenergic blocking agents on ventricular Tachycardia induced by benzene and adrenaline in rat



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G P Thomas


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Several adrenergic antagonists such as phenoxybenzamine and phentolamine (non-specific alpha), prazosin (alpha1), yohimbine (alpha2), propranolol (non-specific beta with membrane stabilizing action), practolol (cardioselective beta), sotalol (non selective beta with no membrane stabilizing action) and labetalol (non selective beta with alpha1 blocking action) were studied for their effects on ventricular tachycardias induced by benzene and adrenaline in anaesthetised rats. All the alpha and beta adrenergic blocking agents examined showed significant antiarrhythmic effect in this model. The relative potencies of alpha blockers were: prazosin > yohimbine > phenoxybenzamine > phentolamine while that of beta blockers were:labetalol > propranolol > practolol > sotalol.






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