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Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 49-51

Reduced phosphoinositide levels in endosulfan treated rat brain



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A Subramoniam


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The influence of the insecticide, endosulfan on the levels of phosphoinositides in rat brain was studied. Single oral administration of endosulfan (15 mg/kg) to rats, after 4 hrs, reduced phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2), without any significant effect on phosphatidylinositol4-phosphate (PIP). On the other hand, daily administration of endosulfan (15 mg/kg) for 16 days caused a marked reduction in the levels of PIP2 and PI and a moderate reduction in PIP. These effects of endosulfan were restored to near normal levels 2 weeks after cessation of the treatment. When the dosage was reduced from 15 to 5 mg/kg daily endosulfan administration for 16 days slightly reduced the levels of PI - without any significant influence on the levels of PIP and PIP2. These studies suggest possible involvement of phosphoinositide messenger system in the neurotoxicity of endosulfan.






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