| SHORT COMMUNICATION
|Year : 1994 | Volume
| Issue : 1 | Page : 46-48
Anti-inflammatory activity of niosome encapsulated diclofenac sodium in arthritic rats
Naresh RA Raja, GK Pillai, N Udupa, G Chandrashekar
Synthetic analogues of liposomes prepared from non-ionic surfactants, known as niosomes, have been used as vesicular drug carriers. Diclofenacsodium has been entrapped in niosomes comprising Tween 85 and Tween 85-poloxamer F 108 mixture. Anti- inflammatory efficacy of these niosomes were compared with that of free diclofenac sodium in adjuvant induced arthritic rats. It was found that the niosomal diclofenac sodium formulations prepared by employing a 1:l combination of Tween 85 and poloxamer F 108 elicits a better and consistent anti-inflammatory activity for more than 72 hours after administration of a single dose.
Naresh RA Raja
Source of Support: None, Conflict of Interest: None