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 RESEARCH PAPER
Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 19-22

Effect of picroliv and silymarin on liver regeneration in rats



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Srivastava Savita


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Picroliv and silymarin are known to provide significant protection against liver damage in rats by hepatotoxic chemicals such as carbon tetrachloride, paracetamol, galactosamine and thioacetamide. Present investigation was undertaken to evaluate the effect of picroliv and silymarin on partially hepatectomized liver of rats utilising macromolecular levels, DNA, RNA synthesis and mitotic figure as indices of regeneration. The levels of DNA, RNA, protein and cholesterol increased in the regenerating liver of rats being maximum at 46 and 120 hours post partial hepatectomy (PPH). DNA and RNA synthesis increased being maximum at 24 hour PPH as indicated by the tritiated thymidine and uridine incorporation studies. Later on mitoticfigure also showed an increasing trend in the residual liver. They were further enhanced when the animals were pretreated with picroliv or silymarin. These results suggest that these agents stimulate liver regeneration in the early stages.






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