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 SHORT COMMUNICATION
Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 234-236

Comparative evaluation of orally and transdermally administered omeprazole against experimentally induced gastric ulcers in rats



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MSP Sastry


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Antiulcer and cytoprotective activity of orally and transdermally administered omeprazole was evaluated and compared in 3 different experimental gastric ulcer models, viz., indomethacin, aspirin + pylorus ligation induced ulcers and 0.6 N HCI induced gastric ulcers and mucosal damage in rats. Omeprazole (5 mg) was administered either orally as enteric coated granules or transdermally as 1% ointment. Ulcerogenecity was significantly reduced after oral and transdermal administration of omeprazole except after its oral administration in aspirin induced ulcers in pylorus ligated rats. Omeprazole produced significantly greater antiulcer activity after transdermal administration in all the models. The results of this study thus indicate a superior antiulcer profile for omeprazole after transdermal administration in rats as compared to the orally given drug.






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