| RESEARCH PAPER
|Year : 1993 | Volume
| Issue : 4 | Page : 224-227
Evidence for alpha-2 adrenoceptor agonist activity of hydralazine
MC Satia, RK Goyal
Hydralazine (5.08 x 10-5 M to 1.5 x 10-3M ) produced a dose-dependent inhibition of field stimulation evoked responses on rat anococcygeus muscle and vas-deferens. This was antagonized competitively by yohimbine. On estrogen primed rat uterus, hydralazine produced a dose-dependent relaxation which was competitively blocked by yohimbine and propranolol but not by cimetidine. The responses to hydralazine were significantly inhibited by reserpine pre-treatment (5mg/kg, i.p., 24 h. before). Our data suggests alpha2-adrenoceptor agonist activity of hydralazine.
M C Satia
Source of Support: None, Conflict of Interest: None