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 RESEARCH PAPER
Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 215-219

IgG.subclass response to cell - and egg grown influenza vaccines in human volunteers



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Ahmeida ETS Ben


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The immunogenicity of two inactivated influenza A (H1 N1) vaccines which were derived either as tissue culture strains in MDCK cells or eggs from virus grown from a single clinical specimen was assessed in a comparative study. An ELISA was used to measure serum IgG and IgG subclass antibody responses in grouped volunteers receiving the vaccines. Both types of vaccines were able to stimulate production of IgG and IgG subclass antibody response, predominantly IgG1 and to a lesser extent lgG3. The results suggest that despite the antigenic differences of the two vaccine virus strains used in this study similar IgG responses were evoked.






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