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 RESEARCH PAPER
Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 204-208

Comparative study of imipramine, maprotiline, fluvoxamine, trazodone and alprazolam in some animal models of depression



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S N Pal


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Antidepressants were compared for their behavioural effects in some animal models of depression. The results were interpreted for a better insight into the underlying mechanisms as well as for a rank ordering of the models. It is concluded that the model of depression involving inescapable foot shock, if considered together with the forced swimming test or the tail suspension test, can more efficiently screen putative antidepressants.






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