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 RESEARCH PAPER
Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 199-203

Modification of disposition kinetics of oxytetracycline by paracetamol and endotoxin - induced fever in goats



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S Manna


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Disposition kinetics of oxytetracycline (20 mg/kg, i.v) in the absence/presence of paracetamol (50 mg/kg, i.v) in both afebrile and endotoxin-induced febrile conditions were studied in female Black Bengal goats. Fever was induced and maintained for 12 h by injecting Escherichia coli endotoxin (0.2 'g/kg, i.v) initially and repeating it at half the dose (0.1 'g/kg) 5h later. The disposition kinetics of oxytetracycline was described by a two compartment open model. The concentrations of oxytetracycline atone (83.60 ˝ 0.80 'g/ml) in afebrile condition at 0.03 hr post- drug administration was higher from the corresponding values of febrile alone (48.30 ˝ 1.60 'g/ml) and combined therapy (72.60 ˝ 4.90 'g/ml; 52.0 ˝ 1.O 'g/ml). Fever alone decreased the concentration of oxytetracycline in blood-The t1/2(() value (5.95 h) was maximum in afebrile paracetamol group followed by febrile alone (4.08 h), febrile paracetamol (3.16 h) and afebrile alone groups (2.78 h) in sequence. The Vd(area) was higher in presence of paracetamol at both afebrile and febrile states as well as febrile alone. The paracetamol did not interfere with the protein binding of oxytetracycline.






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