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Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 181-187

Role of hypertension control in diabetes - mellitus and the agents of choice



Correspondence Address:
R K Goyal


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Hypertension and diabetes mellitus are the chronic conditions which frequently coexist and can affect individual health care needs. Hypertension appears to be critically important in a diabetic patient, not only because of its increased prevalence, but also because it accelerates both the micro- and macrovascular complications of diabetes mellitus. In a therapeutic approach, the treatment with antihypertensive agents in a diabetic subject should not only be efficacious and well tolerated, but should reverse or prevent diabetes induced alterations in lipid levels, cardiovascular changes, and progress of renal failure. Moreover metabolic control of diabetes mellitus should not be affected by these agents. For this reason, new and improved antihypertensive drugs with multiple actions are of particular interest. Angiotensin converting enzyme inhibitors have a good therapeutic potential for the treatment of hypertension in diabetic patients. Centrally acting agents clonidine and vasodilator, prazosin, also appear to be promising but more studies are warranted for these two drugs. Cardioselective b-blockers should be used with caution and only in low to moderate doses. More studies are required to provide the rationale basis for the use of antihypertensives for the treatment of hypertensive diabetics,






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