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 RESEARCH PAPER
Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 146-148

Drug interaction of tolbutamide with ketoconazole in diabetic rabbits



Correspondence Address:
YSR Krishnaiah


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A study was carried out to find out the therapeutic implications of the tolbutamide - ketoconazole interaction in diabetic rabbits. Ketoconazole treatment (20 mgkg, oral once daily for one week) significantly increased and prolonged the antidiabetic effect of tolbutamide (40 mg/kg, oral) in diabetic rabbits. The AUC0-( and the terminal half-life of tolbutamide were increased significantly by ketoconazole indicating the decrease in its hepatic metabolism.






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