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 RESEARCH PAPER
Year : 1993  |  Volume : 25  |  Issue : 3  |  Page : 140-145

Effect of lead on 5-hydroxytryptamine induced contractions in rat ileum and its modification by magnesium and reserpine



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D N Gandhi


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Effects of lead (Pb) on 5-hydroxytryptamine (5-HT) induced contractions of isolated rat ileum and its modification by magnesium (Mg++) and reserpine were studied. Preparations incubated in Mg++ free or excess Mg++media showed supersensitivity and subsensitivity to 5-HT respectively. Reserpinization failed to induce supersensitivity to 5-HTin any Mg++ concentration of the medium, but in Mg++ free with ethylene diamine tetra acetic acid (EDTA) showed increased sensitivity to 5-HT. The inhibition observed with Pb in Mg++ with EDTA was comparatively less in both non-reserpinized and reserpinized preparations. Pb reduced the sensitivity and decreased the maximal responses to 5-HT in all Mg++ concentration of the medium tested.






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