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 RESEARCH PAPER
Year : 1993  |  Volume : 25  |  Issue : 2  |  Page : 95-98

Studies on diuretic effect of ST-93: A clonidine analog



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R Kaushal


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ST-93 induced significant diuresis in rats. Dose-dependent effects were observed in urine volume and electrolyte excretion. Dose-related natriuretic and chloruretic activities were noticed. Prazosin and yohimbine significantly antagonised diuresis of ST- 93, while propranolol, cimetidine, cyproheptadine, naloxone and bicuculline had no such effect. The data suggest the possible involvement of both alpha-l and alpha-2 adrenoceptors in the diuretic effect of ST 93 in rats.






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