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Year : 1992  |  Volume : 24  |  Issue : 4  |  Page : 229-230

Beneficial effect of xanthinol nicotinate in experimental aluminium phosphide poisoning



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C S Gautam


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The LD50 of aluminium phosphide (ALP) was determined in the rat and the beneficial effect of xanthinol nicotinate on survival rate was studied. The LD50 of ALP by oral route was 5.66 mg/kg. The survival rate of rats at the end of 24 hours observation period following oral administration of ALP 5.9 mg/kg in two groups of control rats was 33.3 and 38.3% Administration of xanthinol nicotinate 100 and 150 mg/kg, i.p. administered every 30 minutes for 8 hours increased the survival rate to 63% and 67% respectively.






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