| RESEARCH PAPER
|Year : 1992 | Volume
| Issue : 4 | Page : 207-211
Synthesis and anti-inflammatory activity of N-pyridinobenzamide-2-carboxylic acid and its metal chelates
Mohan Govind, Nagar Rajesh
N-pyridino benzamide-2-carboxylic acid (PBCA) and its Cu(ll), Ni(ll), Co(ll), Zn(II) and Mn(ll) complexes have been synlhesized and characterised by their elemental analysis, molecular weight determination, molar conductance, infrared and electronic spectra and magnetic measurements. In acute antiinflammatory tests, all the compounds except manganese chelate were found active with a maximum activity of cobalt complex (32.8%), whereas copper chelate was most active in cotton pellet granuloma test and zinc chelate in adjuvant test. The ulcerogenic potential markedly reduced after chelation with copper followed by zinc, cobalt, manganese and nickel complexes.
Source of Support: None, Conflict of Interest: None