| SHORT COMMUNICATION
|Year : 1992 | Volume
| Issue : 3 | Page : 166-168
Plasma disposition and biodistribution studies on gentamicin in rabbits
RP Uppal, Garg Satish, SP Verma, RK Roy
The plasma disposition biodistribution and dosage regimens of gentamicin were studied in rabbits tollowing i.v. administration (4 mg/Kg). The distribution and elimination half-life values were calculated to be 0.38˝ 0.07 and 2.88˝ 0.33 h, respectively. The concentration of gentamicin was found to be highest in kidneys, both at 10 min and 1 h while adrenals revealed absence of the drug. Based on kinetic parameters, satisfactory i.v. dosage regimens of gentamicin in rabbits would be 10.02 and 8.71 mg/Kg as the loading and maintenance doses, respectively, to be repeated at 8 h intervals.
R P Uppal
Source of Support: None, Conflict of Interest: None