IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1249 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1176    
    Printed76    
    Emailed1    
    PDF Downloaded94    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1992  |  Volume : 24  |  Issue : 3  |  Page : 158-162

Potentiation of chloroquine action against Plasmodium falciparum in vitro by verapamil and cyproheptadine



Correspondence Address:
N Valecha


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

The effects of verapamil and cyproheptadine in combination with chloroquine were examined against P.falciparum in vitro. Verapamil at 0.3-4.0 x 1O-6 mol/L blood potentiated the effects of chloroquine against chloroquine sensitive and chloroquine resistant isolates of P. falciparum in vitro. Verapamil acts both on early and late developmental stages of the parasite. Cyproheptadine in the conc. range of 0.6-2.4 x 10-6 mol/L blood potentiated the effects of chloroquine against chloroquine sensitive and resistant P. falciparum isolates. The combination of chloroquine and cyproheptadine may be of value and further studies seem to be justified.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow