| RESEARCH PAPER
|Year : 1992 | Volume
| Issue : 3 | Page : 158-162
Potentiation of chloroquine action against Plasmodium falciparum in vitro by verapamil and cyproheptadine
N Valecha, S Biswas, A Srivastava, Devi Usha
The effects of verapamil and cyproheptadine in combination with chloroquine were examined against P.falciparum in vitro. Verapamil at 0.3-4.0 x 1O-6 mol/L blood potentiated the effects of chloroquine against chloroquine sensitive and chloroquine resistant isolates of P. falciparum in vitro. Verapamil acts both on early and late developmental stages of the parasite. Cyproheptadine in the conc. range of 0.6-2.4 x 10-6 mol/L blood potentiated the effects of chloroquine against chloroquine sensitive and resistant P. falciparum isolates. The combination of chloroquine and cyproheptadine may be of value and further studies seem to be justified.
Source of Support: None, Conflict of Interest: None